Oscillatory fluid flow influences primary cilia and microtubule mechanics

Fluid mechanics of nodal flow due to embryonic primary cilia.

Breaking of left-right symmetry is crucial in vertebrate development. The role of cilia-driven flow has been the subject of many recent publications, but the underlying mechanisms remain controversial. At approximately 8 days post-fertilization, after the establishment of the dorsal-ventral and anterior-posterior axes, a depressed structure is found on the ventral side of mouse embryos, termed ...

Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx.

Primary cilia are hypothesized to act as a mechanical sensor to detect renal tubular fluid flow. Anomalous structure of primary cilia and/or impairment of increases in intracellular Ca2+ concentration in response to fluid flow are thought to result in renal cyst formation in conditional kif3a knockout, Tg737 and pkd1/pkd2 mutant mice. The mutant inv/inv mouse develops multiple renal cysts like ...

Fluid Mechanics and Multiphase Flow in Pipelines

Fluid mechanics, turbulent flow and turbulence modeling

This course material is used in two courses in the International Master’s programmeAppliedMechanics at Chalmers. The two courses are TME225 Mechanics of fluids (Chapters 1-10), and MTF270 Turbulence Modeling (Chapters 11-27). MSc students who follow these courses are supposed to have taken one basic course in fluid mechanics. The lecture notes are also used in the three-day course Unsteady Simu...

Mechanical properties of primary cilia regulate the response to fluid flow.

The primary cilium is a ubiquitous organelle present on most mammalian cells. Malfunction of the organelle has been associated with various pathological disorders, many of which lead to cystic disorders in liver, pancreas, and kidney. Primary cilia have in kidney epithelial cells been observed to generate intracellular calcium in response to fluid flow, and disruption of proteins involved in th...